PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate
0 ImagesCat. No.: HY-W052626CAS No.: 142733-64-0
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Methyl 6-aminohexanoate hydrochloride
0 ImagesCat. No.: HY-W008066CAS No.: 1926-80-3
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1-(Boc)-3-Fluoropiperidine-4-carboxylic acid
0 ImagesCat. No.: HY-W001393CAS No.: 1303974-46-0
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8-Boc-2,8-Diazaspiro[4.5]decane hydrochloride
![8-Boc-2,8-Diazaspiro[4.5]decane hydrochloride](https://file.medchemexpress.com/product_pic/hy-30592.gif "Click to View 8-Boc-2,8-Diazaspiro[4.5]decane hydrochloride Product Detail")
0 ImagesCat. No.: HY-30592CAS No.: 851325-42-3
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2-Propargyl-(trans)-4-cyclohexanediamine hydrochloride
0 ImagesCat. No.: HY-W060233CAS No.: 1313279-48-9
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tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylate
![tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056295.gif "Click to View tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056295CAS No.: 1434141-69-1
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tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate
0 ImagesCat. No.: HY-W020221CAS No.: 98642-44-5
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5-(Benzyloxy)pentan-1-ol
0 ImagesCat. No.: HY-W009930CAS No.: 4541-15-5
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tert-Butyl (7-bromoheptyl)carbamate
0 ImagesCat. No.: HY-W036393CAS No.: 142356-34-1
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5-Chloropentan-1-ol
0 ImagesCat. No.: HY-W038345CAS No.: 5259-98-3
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N-Boc-undecane-1,11-diamine
0 Imagestert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. tert-Butyl (11-aminoundecyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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Biotin-PEG2-acid
0 ImagesBiotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
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Azetidine-3-carboxylic acid
0 ImagesAzetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
